研究業績１（英文論文）

下記は中島教授が関連するもので，下線は教室員です．

291.

Battulga, T., Tumurbaatar, O., Ganzorig, O., Ishimura, T., Kanamoto, T., Nakashima, H., Miyazaki, K., and Yoshida, T.

Analysis of interaction between sulfated polysaccharides and HIV oligopeptides by surface plasmon resonance.

Int. J. Biol. Macromol., 125; 909-914, 2019.

290.

Kanamoto, T., Terakubo, S. and Nakashima, H.

Antimicrobial susceptibilities of oral isolates of Abiotrophia and Granulicatella according to the consensus guidelines for fastidious bacteria.

Medicines (Basel), 5, pii: E129, 2018.

289.

Asai, D., and Nakashima, H.

Pathogenic viruses commonly present in the oral cavity and relevant antiviral compounds derived from natural products.

Medicines (Basel), 5, pii: E120, 2018.

288.

Takemura, H., Terakubo, S., Okamura, N., and Nakashima, H.

The reduction of L-cystine to L-cysteine in the supernatant of A549 cell culture causes imipenem inactivation.

J. Infect. Chemother., 24; 341-346, 2018.

287.

Asai, D., Kanamoto, T., Takenaga, M. and Nakashima, H.

In situ depot formation of anti-HIV fusion-inhibitor peptide in recombinant protein polymer hydrogel.

Acta Biomater., 64; 116-125, 2017.

286.

Sakagami, H., Uesawa, Y., Masuda, Y., Tomomura, M., Yokose, S., Miyashiro, T., Murai, J., Takao, K., Kanamoto, T., Terakubo, S., Kagaya, H., Nakashima, H., and Sugita, Y.

Quantitative structure-cytotoxicity relationship of newly synthesized piperic acid esters.

Anticancer Res., 37; 6161-6168, 2017.

285.

Suzuki, R., Sakagami, H., Amano, S., Fukuchi, K., Sunaga, K., Kanamoto, T., Terakubo, S., Nakashima, H., Shirataki, Y., Tomomura, M., Masuda, Y., Yokose, S., Tomomura, A., Watanabe, H., Okawara, M., and Matahira, Y.

Evaluation of biological activity of mastic extracts based on chemotherapeutic indices.

In Vivo, 31; 591-598, 2017.

284.

Sakagami, H., Masuda, Y., Tomomura, M., Yokose, S., Uesawa, Y., Ikezoe, N., Asahara, D., Takao, K., Kanamoto, T., Terakubo, S., Kagaya H, Nakashima, H., and Sugita, Y.

Quantitative structure-cytotoxicity relationship of chalcones.

Anticancer Res., 37; 1091-1098, 2017.

283.

Fukuchi, K., Okudaira, N., Adachi, K., Odai-Ide, R., Watanabe, S., Ohno, H., Yamamoto, M., Kanamoto, T., Terakubo, S., Nakashima, H., Uesawa, Y., Kagaya, H., and Sakagami, H.

Antiviral and antitumor activity of licorice root extracts.

In Vivo, 30; 777-785, 2016.

282.

Asai, D., Murata, M., Toita, R., Kawano, T., Nakashima, H., and Kang. J.H.

Role of amino acid residues surrounding the phosphorylation site in peptide substrates of G protein-coupled receptor kinase 2 (GRK2).

Amino Acids, 48; 2875-2880, 2016.

281.

Sakagami, H., Fukuchi, K., Kanamoto, T., Terakubo, S., Nakashima, H., Natori, T., Suguro-Kitajima, M., Oizumi, H., Yasui, T., and Oizumi, T.

Synergism of alkaline extract of the leaves of Sasa senanensis Rehder and antiviral agents.

In Vivo, 30; 421-426, 2016.

280.

Muschin, T., Budragchaa, D., Kanamoto, T., Nakashima, H., Ichiyama, K., Yamamoto, N., Shuqin, H., and Yoshida, T.

Chemically sulfated natural galactomannans with specific antiviral and anticoagulant activities.

Int. J. Biol. Macromol., 89; 415-420, 2016.

279.

Tuvaanjav, S., Shuqin, H., Komata, M., Ma, C., Kanamoto, T., Nakashima, H., and Yoshida, T.

Isolation and antiviral activity of water-soluble Cynomorium songaricum Rupr. polysaccharides.

J. Asian Nat. Prod. Res., 18; 159-171, 2016.

278.

Bai, S., Budragchaa, D., Han, S., Kanamoto, T., Nakashima, H., and Yoshida, T.

Sulfated alkyl glucopyranans with potent antiviral activity synthesized by ring-opening copolymerization of anhydroglucose and alkyl anhydroglucose monomers.

Int. J. Polym. Sci., 2015, pii: 317420, 2015

277.

Sakagami, H., Uesawa, Y., Ishihara, M., Kagaya, H., Kanamoto, T., Terakubo, S., Nakashima, H., Takao, K., and Sugita, Y.

Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.

Anticancer Res., 35; 5341-5351, 2015.

276.

Uesawa, Y., Sakagami, H., Ishihara, M., Kagaya, H., Kanamoto, T., Terakubo, S., Nakashima, H., Yahagi, H., Takao, K., and Sugita, Y.

Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.

Anticancer Res., 35; 5299-5307, 2015.

275.

Kanehashi, S., Masuda, R., Yokoyama, K., Kanamoto, T.,  Nakashima, H., and Miyakoshi, T.

Development of a cashew nut shell liquid (CNSL)-based polymer for antibacterial activity.

J. Appl. Polym. Sci., 132; pii: 42725, 2015

274.

Takenaga, M., Yamamoto, Y., Takeuchi T., Ohta, Y., Tokura, Y., Hamaguchi, A., Asai, D., Nakashima, H., Oishi, S., and Fujii, N.

Potential new chemotherapy strategy for human ovarian carcinoma with a novel KSP inhibitor.

Biochem. Biophys. Res. Commun., 463; 222-228, 2015.

273.

Takemura H., Ohno, H., Miura, I., Takagi, T., Ohyanagi, T., Kunishima, H., Okawara, A., Miyazaki, Y., and Nakashima, H.

The first reported case of central venous catheter-related fungemia caused by Cryptococcus liquefaciens.

J. Infect. Chemother., 21; 392-394, 2015.

272.

Budragchaa, D., Bai, S., Kanamoto, T., Nakashima, H., Han, S., Saito, T., and Yoshida, T.

Synthetic galactomannans with potent anti-HIV activity.

Carbohydr. Polym., 130; 233-242, 2015.

265.

Sakagami, H., Ohkoshi, E., Amano, S., Satoh, K., Kanamoto, T., Terakubo, S., Nakashima, H., Sunaga, K., Otsuki, T., Ikeda, H., and Fukuda T.

Effcient utilization of plant resources by alkaline extraction.

Altern. Integr. Med., 2, pii: 1000133, 2013.

264.

Bo, S., Muschin, T., Kanamoto, T., Nakashima, H., and Yoshida T.

Sulfation and biological activities of konjac glucomannan.

Carbohydr. Polym., 94; 899-903, 2013

263.

Sakagami, H., Amano, S., Yasui, T., Satoh, K., Shioda, S., Kanamoto, T., Terakubo, S., Nakashima, H., Watanabe, K., Sugiura, T., Kitajima, M., Oizumi, H., and Oizumi, T.

Biological interaction between Sasa senanensis Rehder leaf extract and toothpaste ingredients.

In Vivo, 27; 275-284, 2013.

262.

Fukuda, T., Iwaki, M., Komiya, T., Shibayama, K., Takahashi, M., and Nakashima, H.

Effects of simultaneous immunization of Haemophilus influenzae type b conjugate vaccine and diphtheria-tetanus-acellular pertussis vaccine on anti-tetanus potencies in mice, guinea pigs, and rats.

Jpn. J. Infect. Dis., 66; 41-45, 2013.

261.

Kato, T., Horie, N., Matsuta, T., Naoki, U., Shimoyama, T., Kaneko, T., Kanamoto, T., Terakubo, S., Nakashima, H., Kusama, K., and Sakagami, H.

Anti-UV/HIV activity of Kampo medicines and constituent plant extracts.

In Vivo, 26; 1007-1013, 2012.

260.

Han, S., Kanamoto, T., Nakashima, H., and Yoshida, T.

Synthesis of a new amphiphilic glycodendrimer with antiviral functionality.

Carbohydr. Polym., 90; 1061-1068, 2012.

259.

Takahashi, K., Otomo, M., Yamaguchi, N., Nakashima, H., and Miyoshi, H.

Substitution of Arg-386 in dynamin 1 middle domain reduces GTPase activity in the absence of lipids and oligomer stability.

Biosci. Biotechnol. Biochem., 76; 2195-2200, 2012.

258.

Sakagami, H., Matsuta, T., Satoh, K., Ohtsuki, S., Shimada, C., Kanamoto, T., Terakubo, S., Nakashima, H., Morita, Y., Ohkubo, A., Tsuda, T., Sunaga, K., Maki, J., Sugiura, T., Kitajima, M., Oizumi, H., Oizumi, T.

Biological activity of SE-10, granulated powder of Sasa senanensis Rehder leaf extract.

In Vivo, 26; 411-418, 2012.

257.

Sakagami, H., Iwamoto, S., Matsuta, T., Satoh, K., Shimada, C., Kanamoto, T., Terakubo, S., Nakashima, H., Morita, Y., Ohkubo, A., Tsuda, T., Sunaga, K., Kitajima, M., Oizumi, H., and Oizumi, T.

Comparative study of biological activity of three commercial products of Sasa senanensis Rehder leaf extract.

In Vivo, 26; 259-264, 2012.

256.

Muschin, T., Han, S., Kanamoto, T., Nakashima, H., and Yoshida T.

Synthesis and specific influenza A virus-adsorptive functionality of alkyl curdlan sulfate-coated membrane filter.

J. Polymer Sci. A Polymer Chem., 49; 3241-3247, 2011.

255.

Sakagami, H., Kawano, M., Thet, M.M., Hashimoto, K., Satoh, K., Kanamoto, T.,

Terakubo, S., Nakashima, H., Haishima, Y., Maeda, Y., Sakurai, K.

Anti-HIV and immunomodulation activities of cacao mass lignin-carbohydrate complex.

In Vivo, 25; 229-236, 2011.

254.

Matsuta, T., Sakagami, H., Satoh, K., Kanamoto, T., Terakubo, S., Nakashima,

H., Kitajima, M., Oizumi, H., and Oizumi, T.

Biological activities of luteolin glycosides and tricin from Sasa senanesis Rehder.

In Vivo, 25; 757-762, 2011.

253.

Sakagami, H., Kushida, T., Oizumi, T., Nakashima, H., and Makino, T.

Distribution of lignin-carbohydrate complex in plant kingdom and its functionality as alternative medicine.

Pharmacol. Ther., 128; 91-105, 2010.

252.

Kawano, M., Sakagami, H., Satoh, K., Shioda, S., Kanamoto, T., Terakubo, S., Nakashima, H., and Makino, T.

Lignin-like activity of Lentinus edodes mycelia extract (LEM).

In Vivo, 24; 543-551, 2010.

251.

Han, S., Yoshida, D., Kanamoto, T., Nakashima, H., Toshiyuki, U., and Yoshida, T.

Sulfated oligosaccharide cluster with polylysine core scaffold as a new anti-HIV dendrimer.

Carbohydr. Polym., 80; 1111-1115, 2010.

250.

Sakagami, H., Zhou, L., Kawano, M., Thet, M.M., Tanaka, S., Machino, M., Amano, S., Kuroshita, R., Watanabe, S., Chu, Q., Wang, Q.T., Kanamoto, T., Terakubo, S., Nakashima, H., Sekine, K., Shirataki, Y., Zhang, C.H., Uesawa, Y., Mohri, K., Kitajima, M., Oizumi, H., and Oizumi, T.

Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder.

In Vivo, 24; 735-743, 2010.

249.

Takahashi, K., Miyoshi, H., Otomo, M., Osada, K., Yamaguchi, N., and Nakashima, H.

Suppression of dynamin GTPase activity by sertraline leads to inhibition of dynamin-dependent endocytosis.

Biochem. Biophys. Res. Commun., 391; 382-387, 2010.

248.

Asai, D., Kuramoto, M., Shoji, Y., Kang, J.H., Kodama, B.K., Kawamura, K., Mori,

T., Miyoshi, H., Niidome, T., Nakashima, H., and Katayama, Y.

Specific transgene expression in HIV-infected cells using protease-cleavable transcription regulator.

J. Control. Release, 141; 52-61, 2010.

247.

Sakagami, H., Kishino, K., Kobayashi, M., Hashimoto, K., Iida, S., Shimetani, A., Nakamura, Y., Takahashi, K., Ikarashi, T., Fukamachi, H., Satoh, K., Nakashima, H., Shimizu, T., Takeda, K., Watanabe, S., and Nakamura, W.

Selective antibacterial and apoptosis-modulating activities of mastic.

In Vivo, 23; 215-224, 2009.

246.

Chu, Q., Satoh, K., Kanamoto, T., Terakubo, S., Nakashima, H., Wang, Q., and Sakagami, H.

Antitumor potential of three herbal extracts against human oral squamous cell lines.

Anticancer Res., 29; 3211-3219, 2009.

245.

Asai, D., Tsuchiya, A., Kang, J.H., Kawamura, K., Oishi, J., Mori, T., Niidome, T., Shoji, Y., Nakashima, H., and Katayama, Y.

Inflammatory cell-specific transgene expression system responding to Ik-B kinase beta activation.

J. Gene Med., 11; 624-632, 2009.

244.

Han, S., Kanematsu, Y., Hattori, K., Nakashima, H., and Yoshida, T.

Ring-opening polymerization of benzylated 1,6-anhydro-beta-D-lactose and specific biological activities of (1->6)-alpha-D-lactopyranans.

J. Polymer Sci. A Polymer Chem., 47; 913-924, 2009.

243.

Asai, D., Kang, J.H., Toita, R., Tsuchiya, A., Niidome, T., Nakashima, H., and Katayama, Y.

Regulation of transgene expression in tumor cells by exploiting endogenous intracellular signals.

Nanoscale Res. Lett., 4;229-233, 2009.

242.

Ishii, Y., Tateda, K., Yamaguchi, K., and The Japan Antimicrobial Resistance

Surveillance Participants Group (JARS)

Evaluation of antimicrobial susceptibility for B-Lactams using the Etest method against clinical isolates from 100 medical centers in Japan (2006).

Diagnostic Micribiology & Infectious Disease, 60; 177-183, 2008.

241.

Kang, J.H., Asai, D., Kim, J.H., Mori, T., Toita, R., Tomiyama, T., Asami, Y., Oishi, J., Sato, Y., Niidome, T., Jun, B., Nakashima, H., and Katayama, Y.

Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Ca activation in cancer cells.

J. Am. Chem. Soc., 130; 14906-14907, 2008.

240.

Sakagami, H., Amano, S., Kikuchi, H., Nakamura, Y., Kuroshita, R., Watanabe, S., Satoh, K., Hasegawa, H., Nomura, A., Kanamoto, T., Terakubo, S., Nakashima, H., Taniguchi, S., Oizumi, T.

Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract.

In Vivo, 22; 471-476, 2008.

239.

Sakagami, H., Satoh, K., Fukamachi, H., Ikarashi, T., Shimizu, A., Yano, K., Kanamoto, T., Terakubo, S., Nakashima, H., Hasegawa, H., Nomura, A.,

Utsumi, K., Yamamoto, M., Maeda, Y., and Osawa, K.

Anti-HIV and vitamin C-synergized radical scavenging activity of cacao husk

lignin fractions.

In Vivo, 22; 327-332, 2008.

238.

Otomo, M., Takahashi, K., Miyoshi, H., Osada, K., Nakashima, H., and Yamaguchi, N.

Some selective serotonin reuptake inhibitors inhibit dynamin I guanosine

triphosphatase (GTPase).

Biol. Pharm. Bull., 31; 1489-1495, 2008.

237.

Miyoshi, H., Okade, H., Muto, S., Suehiro, N., Nakashima, H., Tomoo, K.,

and Natsuaki, T.

Turnip mosaic virus VPg interacts with Arabidopsis thaliana eIF(iso)4E and inhibits in vitro translation.

Biochimie, 90; 1427-1434, 2008.

236.

Asai, D., Kodama, B.K., Shoji, Y., Nakashima, H., Kawamura, K., Oishi, J., Kuramoto, M., Niidome, T., and Katayama, Y.

Drug delivery system based on responses to an HIV infectious signal.

Med. Chem., 4; 386-391, 2008.

230.

Muto, S., Miyoshi, H., Nishikawa, H., and Nakashima, H.

Novel recognition sequence of coxsackievirus 2A protease.

Biochem. Biophys. Res. Commun., 348; 1436-1442, 2006.

229.

Kodama, K., Katayama, Y., Shoji, Y., and Nakashima, H.

The features and shortcomings for gene delivery of current novel-viral carriers.

Curr. Med. Chem., 13; 2155-2161, 2006.

228.

Sakagami, H., Asano, K., Satoh, K., Takahashi, K., Terakubo, S., Shoji, Y., Nakashima, H., and Nakamura, W.

Anti-stress activity of mulberry juice in mice.

In Vivo, 20; 499-504, 2006.

227.

Akatsu, Y., Ohshima, N., Yamagishi, Y., Nishishiro, M., Wakabayashi, H., Kurihara, T., Kikuchi, H., Katayama, T., Motohashi, N., Shoji, Y., Nakashima, H., and Sakagami, H.

Apoptosis-inducing activity of trihaloacetylazulens against human oral tumor cell lines.

Anticancer Res., 26; 1917-1924, 2006.

226.

Tamamura, H., Tsutsumi,  H., Masuno, H., Mizokami, S., Hiramatsu, K., Wang, Z., Trent, J.O., Nakashima, H., Yamamoto, N., Peiper, S. C., and Fujii, N.

Develpoment of a linear typr of low molecular weight CXCR4 antagonists based on T140 analogs.

Org. Biomol. Chem., 4; 2354-2357, 2006.

225.

Tamamura, H., Ojiya, A., Ogawa, T., Tsutsumi, H., Masuno, H., Nakashima, H., Yamamoto, N., Hamachi, I., and Fujii, N.

Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure.

J. Med. Chem., 49; 3412-3415, 2006.

216.       Tamamura, H., Hiramatsu, K., Ueda, S., Wang, Z., Kusano, S., Terakubo, S., Trent, J. O., Peiper, S. C.,  Yamamoto, N.,  Nakashima, H.,  Otaka, A. and Fujii, N.:

Stereoselective synthesis of [L-Arg-L/D-3(2-naphthyl)alanine]-type(E)- alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131.,

J. Med. Chem., 48; 380-391, 2005.

217.       Sakagami, H., Matsumoto, H., Satoh, K., Shioda, S., Ali, C. S., Hashimoto, K., Kikuchi, H., Nishikawa, H., Terakubo, S., Shoji, Y., Nakashima, H. and Shimada, J.:

              Cytotoxicity and radical modulating activity of Moxa smoke.,

              In Vivo, 19; 391-398,  2005.

218.       Tamamura, H., Araki, T., Ueda, S., Wang, Z., Oishi, S., Esaka, A., Trent, J. O., Nakashima, H.,  Yamamoto, N.,  Peiper, S. C.,  Otaka, A. and Fujii, N.:

Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide-scahffolds.,

J. Med. Chem., 48; 3280-3289, 2005.

219.        Wakabayashi, H., Nishishiro, M., Arikawa, S., Hashimoto, K., Kikuchi, H.,  

Nishikawa, H., Kurihara, T., Terakubo, S., Shoji, Y., Nakashima, H., Motohashi, N. and Sakagami, H.:

              Cytotoxic activity of Azulenequinones against human oral tumor cell lines.,

Anticancer Res., 25; 305-312, 2005.

220.       Shirataki, Y., Kawase, M., Sakagami, H.,  Nakashima, H., Tani, S.,    Tanaka, T., Sohara, Y., Schelz, Z., Molnar, J.,  and  Motohashi, N.:

              Bioactivities of Anastasia Black (Russian Sweet Peper).,

Anticancer Res., 25; 1991-2000, 2005.

221.       Motohashi, N., Wakabayashi, H., Kurihara, T., Fukushima, H., Yamada, T., Kawase, M., Sohara, Y., Tani, S., Shirataki, Y., Sakagami, H., Satoh, K., Nakashima, H., Molnar, A., Spengler, G., Gyemant, N., Ugocsai, K. and Molnar, J.:

              Biological activity of Barbados cherry (Acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions.

              Phytother. Res., 18; 212-223, 2005.

222.              Tamamura, H., Esaka,A., Ogawa,T., Araki,T., Ueda,S., Wang,Z., Trent,J. O., 

Tsutsumi, H., Masuno,H.,  Nakashima,H., Yamamoto,N.,  Peiper,S. C.,        

Otaka, A. and Fujii, N.:

Structure–activity relationship studies on CXCR4 antagonists having

cyclic pentapeptide scaffolds.

Org. Biomol. Chem., 3; 4392-4394, 2005.

223.               Molnar, P., Kawase, M., Satoh, K., Sohara, Y., Tanaka, T., Tani, S.,  Sakagami, H., Nakashima, H., Motohashi, N., Gyemant, N. and Molnar, J.:

Biological activity of carotenoids in Red Paprika, Valencia Orange and Golden Delicious Apple.,

Phytother. Res.,19; 700-707, 2005.

224.               Kodama, K.,  Shoji, Y.,  Nakashima, H., Kawamura, K., Ohishi, J., 

Niidome, T. and Katayama, Y.:

Artificial gene regulation system responding to HIV protease.,

Proceeding of 32nd Annual Meeting & Exposition, Florida, U.S.A. of the Controlled Release Society, 18-22  June,  2005.

208.       Shoji, Y. and  Nakashima, H.:

              Current status of delivery systems to improve target efficacy of

              oligonucleotides.,

              Curr. Pharm. Des., 10; 785-796, 2004.

209.       Tamamura, H., Mizumoto, M., Hiramatsu, K., Kusano, S., Terakubo, S., Yamamoto, N., Trent, J. O., Wang, Z., Peiper, S. C., Nakashima, H., Otaka, A. and Fujii, N.:                                                       

              Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides.,

              Org. Biomol. Chem,  2; 1255-1257, 2004.

210.               Miyano-Kurosaki, N., Barnor, J. S., Takeuchi, H., Owada, T., Nakashima, H.,

              Yamamoto, N., Matsuzaki, T., Shimada, F. and Takaku, H.:

In vitro and in vovo transport and delivery of phosphorothioate oligonucleotides with cationic liposomes.

Antiviral Chem. Chemother., 15; 93-100, 2004. 

211.        Nakashima, H.:

Anti-HIV and anti-cancer activity of sulfated alkyl oligosaccharides and synthetic peptides.

J. Northwest Normal University (Special Issue for 3rd International Symposium on High-Tech Polymers and Polymeric Complexes), 40(suppl); 25,2004.

212.       Takenaga, M., Tamamura, H., Hiramatsu, K., Nakamura, N., Yamaguchi, Y., Kitagawa, A., Kawai, S., Nakashima, H., Fujii, N., Igarashi, R. :

A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanoma.,

              Biochem. Biophys.Res. Commun., 320; 226-232, 2004. 

213.       Tamamura, H., Fujisawa, M., Hiramatsu, K., Kusano, S., Mizumoto, M., Nakashima, H., Yamamoto, N., Otaka, A. and Fujii, N.:               

              Identification of a CXCR4 antagonist, a T140 analog, as an         anti-rheumatoid arthritis agent.,

              FEBS Lett., 569; 99-104, 2004.

214.       Shoji, Y. and Nakashima, H. :

              Nutraceutics and delivery systems.

              J Drug Target., 12;  385-391, 2004.

215.       Rao, B. K., Kawase, M., Tanaka, T., Tani, S., Motohashi, N., Satoh, K., Sakagami , H., Terakubo, S., Nakashima, H.,  Wolfard, K. and Molnar J.:

Biological activity of an Indian medical plant, Indigofera cordifolia.,

Oriental Pharm. Exp. Med., 4;179-185, 2004.

198.       Fujii, N.,   Nakashima, H.,  and  Tamamura, H.:

              The therapeutic potential of CXCR4 antaginist in the treatment of HIV.,

              Expert Opin. Investig. Drugs, 12; 185-195, 2003.

199.       Motohashi, N., Wakabayashi, H., Kurihara, T., Takada, Y., Maruyama, S., Sakagami, H., Nakashima, H., Tani, S., Shirataki, Y., Kawase, M., Wolfard, K. and Molnar, J.:

Cytotoxic and multidrug resistance reversal activity of a vegetable, ‘Anastasia Red’, a variety of sweet pepper.,

              Phytother. Res., 17; 348-352, 2003.

200.       Kawase, M.,  Motohashi, N., Satoh, K., Sakagami, H., Nakashima, H.,   Tani, S.,  Shirataki, Y., Kurihara, T., Spengler, G., Wolfard, K. and    Molnar, J.:             

              Biological activity of persimmon (Diospyros kaki) peel extracts.,

              Phytother.  Res., 17; 495-500, 2003.

201.               Tamamura, H., Hori, A., Kanzaki, N., Hiramatsu, K., Mizumoto, M., Nakashima, H., Yamamoto, N., Otaka, A. and Fujii, N.:

T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer.,

FEBS Lett., 550; 79-83, 2003.

202.               Tamamura, H., Hiramatsu, K., Kusano, S., Terakubo, S., Yamamoto, N.,  Trent, J. O., Wang, Z., Peiper, S. C.,  Nakashima, H., Otaka, A. and Fujii, N.:

Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives.,

Org. Biomol. Chem., 1; 3656-3662, 2003.

203.               Tamamura, H., Hiramatsu, K., Mizumoto, M., Ueda, S., Kusano, S.,  Terakubo, S., Akamatsu, M., Yamamoto, N.,  Trent, J. O., Wang, Z.,    Peiper, S. C.,  Nakashima, H.,  Otaka, A. and Fujii, N.:

Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists.,

Org. Biomol. Chem., 1; 3663-3669, 2003.

204.               Wakabayashi, H., Hashiba, K., Yokoyama, K., Hashimoto, K., Kikuchi, H., Nishikawa, H., Kurihara, T., Satoh, K., Shioda, S., Saito, S., Kusano, S., Nakashima, H.,  Motohashi, N. and Sakagami, H.:

Cytotoxic acticvity of Azulens against human oral tumor cell lines.,

Anticancer Res., 23; 4747-4756, 2003.

205.               Wakabayashi, H., Yokoyama, K., Hashiba, K., Hashimoto, K., Kikuchi, H., Nishikawa, H., Kurihara, T., Satoh, K., Shioda, S., Muto, S., Terakubo, S., Nakashima, H.,  Motohashi, N. and Sakagami, H.:

Cytotoxic acticvity of Tropolones against human oral tumor cell lines.,

Anticancer Res., 23; 4757-4764, 2003.

206.               Takemura, H., Terakubo, S., Yamamoto, H., Shimada, J., Nakashima, H.  and Kanemitsu, K.:

              Susceptibilities of Fluoroquinolone-resistant Haemophilus parainfluenzae isolates from

              Japanese patients with respiratory infections to five Fluoroquinolones and other

              antimicrobial agents.;

              Antimicrob. Agents Chemother., 47; 3996-3997,  2003.

207.               Fujii, N., Oishi, S., Hiramatsu, K., Araki, T., Ueda, S., Tamamura, H., Otaka, A., Kusano, S., Terakubo, S., Nakashima, H., Broach, J.A., Trent, J.O., Wang, Z.X., and  Peiper, S.C.:

Molecular-size reduction of a potent CXCR4-chemokine antagonist using  

orthogonal combination of conformation- and sequence-based libraries.,

              Angew. Chem. Int. Ed. Engl., 42; 3251-3253, 2003.

189.       Tamamura, H., Omagari, A., Hiramatsu, K., Oishi, S., Habashita, H., 

Kanamoto, T., Gotoh, T., Yamamoto, N.,  Nakashima, H., Otaka, A.

and  Fujii, N.:

Certification of the critical importance of L-3-(2-Naphthyl)alanine at position 3 of a specific CXCR4 inhibitor, T140, leads to an exploratory performance of its downsizing study.,

              Bioorg. Med. Chem., 10; 1417-1426, 2002.

190.       Tamamura, H., Hiramatsu, K., Miyamoto, K., Omagari, A., Oishi, S., Nakashima, H., Yamamoto, N., Kuroda, Y., Nakagawa, T., Otaka, A. and Fujii, N.:

Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140 : the insertion of an (E)-alkene dipeptide isostere into the II’-turn moiety.,

              Bioorg. Med. Chem. Lett.,12; 923-928, 2002. 

191.       Miyamoto, M., Sakagami,  H., Minagawa, K., Kikuchi, H., Nishikawa, H., Satoh, K., Komatsu, N., Fujimaki, M., Nakashima, H., Gupta, M., Sarma, D.N.K. and Mitra, S.K.:     

              Tumor-specificicity and radical scavenging activity of poly-herbal formula.,

              Anticancer Res., 22; 1217-1224, 2002.

192.       Mihara, S., Unten, S., Kakuta, H., Satoh, K., Negpro, T., Nakashima, H., Komatsu, N.,  Fujimaki, M., Kikuchi, H., Nishikawa, H., Minagawa, K., Suzuki, F., Satoh, T.  and  Sakagami, H.:

              Diverse biological activities of fermented pine seed shell extract.,

              Anticancer Res., 22; 1569-1574, 2002.

193.       Motohashi, N., Shirataki, Y., Kawase, M., Tani, S., Sakagami, H., Satoh, K.,  Kurihara, T., Nakashima, H., Mucsi, I., Varga, A. and  Molnar, J.:

Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts.,

J. Ethnopharmacol., 81; 357-364, 2002.

194.       Inagawa, T., Nakashima, H., Karwowski, B., Guga, P., Stec, W. J., Takeuchi, T. and Takaku, H.:                                                

              Inhibition of human immunodeficiency virus type 1 replication by P-stereodefined oligo(nucleoside phosphorothioate)s in a long-term infection model.,

              FEBS Lett., 528; 48-52, 2002.

195.       Nemoto, Y., Satoh, K., Toriizuka, K., Hirai, Y., Tobe, T., Sakagami, H., Nakashima, H.,  and  Ida, Y.:                                                  

              Cytotoxic and radical scavenging activity of blended herbal extracts.,

              In Vivo, 16; 327-332, 2002.

196.       Hatsukari, I.,  Hitosugi, N.,  Ohno, R.,  Nakamura, S., Mizutani, S., Nagasaka, H.,  Matsumoto, I.,  Kikuchi, H.,  Nishikawa, H., Niitsu, H., Kawase, M., Negoro, T.,  Satoh, K.,  Nakashima, H.,  and  Sakagami, H. :

Partial purification of cytotoxic substances from Moxa extract.,

              Anticancer Res.,   22;  2777-2782,  2002.

197.       Miyamoto, M., Hashimoto, K., Minagawa, K., Satoh, K., Komatsu, N., Fujimaki, M., Nakashima, H.,  Yokote, Y., Akahane, K., Gupta, M., Sarma, D.N.K., Mitra, S.K.  and  Sakagami, H. :

Effect of poly-herbal formula on NO production by LPS-stimulated mouse macrophage-like cells.,

              Anticancer Res., 22; 3293-3302, 2002.

169.       Yoshida, Y., Kang, B.W., Hattori, K., Mimura, T., Kaneko, Y., Nakashima,  H., Premanathan, M., Aragaki, R., Yamamoto, N. and  Uryu, T.: 

              Anti-HIV activity of sulfonated arabinofuranan and 　　　

　　        xylofuranan., 

              Carbohydr. Polym., 44; 141-150, 2001.

170.       Tamamura, H., Sugioka, M., Odagaki, Y., Omagari, A., Kan, Y., Oishi, S., Nakashima, H., Yamamoto, N. , Peiper S.C., Hamanaka, N., Otaka, A. and Fujii, N.:  

Conformational study of highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity.,

              Bioorg. Med. Chem. Lett., 11; 359-362, 2001.

171.       Kanamoto, T.,  Kashiwada, Y.,  Kanbara, K., Gotoh, K.,Yoshimori, M.,  Goto, T.,  Sano, K.  and  Nakashima, H.:

Anti-HIV activity of YK-FH312 ( a Betulinic acid derivative),    a novel compound blocking viral maturation.,

              Antimicrob. Agents Chemother, 45; 1225-1230, 2001. 

172.       Gotoh, K.,Yoshimori, M., Kanbara, K., Tamamura, T., Kanamoto, T., Mochizuki, K.,  Fujii, N.  and  Nakashima, H.:

Increase of R5 HIV-1 inhibition and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1.,

              J. Infecti.  Chemother., 7; 28-36, 2001.

173.       Kobayashi, N., Unten, S., Kakuta, H., Komatsu, N., Fujimaki, M., Satoh, K.,  Aratsu, C., Nakashima, H., Kikuchi, H., Ochiai, K. and Sakagami, H.:

              Diverse biological activity of healthy foods.,

              In Vivo, 15; 17-24, 2001.

174.               Ueki, M., Watanabe, S., Ishii, Y., Okunaka, O., Uchino, K., Saitoh, T., Higashi, K., Nakashima, H., Yamamoto, N. and Ogawara, H.: 

              Synthesis and anti-HIV activity of nonatyrosine N- and O 1-9-decasulfate.,

              Bioorg.  Med.  Chem., 9; 477-486, 2001.

175.               Ueki, M., Watanabe, S., Saitoh, T., Higashi, K., Nakashima, H., Yamamoto, N. and Ogawara, H.: 

              Synthesis and chain length --  anti-HIV activity relationship of fully N- and O-sulfated

              homooligomers of Tyrosine.,

              Bioorg. Med. Chem., 9; 487-492, 2001.

176.       Jiang,Y., Satoh, K., Aratsu, C., Komatsu, N., Fujimaki, M.,  Nakashima, H.,  Kanamoto, T., and Sakagami, H.:

              Diverse biological activity of polycaphenol.,

              In Vivo, 15; 145-150, 2001. 

177.       Kanbara, K., Sato, S., Tanuma, J., Tamamura, H., Gotoh, K., Yoshimori, M.,  Kananoto, T., Kitano, M., Fujii, N. and  Nakashima, H.:

Biological and genetic characterization of a human immunodeficiency virus srain resistant to CXCR4 antagonist T134.,

              AIDS Res. Human Retroviruses, 17; 615-622, 2001.

178.       Chiba, H., Inokoshi, J., Okamoto, M., Asanuma, S., Matsuzaki, K., Iwama, M.,      Mizumoto, K., Tanaka, H., Oheda, M., Fujita, K., Nakashima, H., Shinose, M., Takahashi, Y. and Omura, S.:

Actinohivin, a novel anti-HIV protein from an actinomycete that inhibits syncytium formation: isolation, characterization, and biological activities.,

              Biochem. Biophysic. Res. Commun., 282; 595-601, 2001.

179.       Shirataki, Y., Motohashi, N.,  Tani, S., Sakagami, H.,  Satoh, K.,   Nakashima, H., Mahapatra, S.K., Ganguly, K., Dastidar, S.G. and  Chakrabarty, A. N. :

              In vitro biological activity of Prenylflavanones.,

              Anticancer Res., 21; 275-280, 2001.

180.      Hitosugi, N., Ohno, R., Hatsukari, I., Mizukami, S., Nagasaka, H.,  Matsumoto, I.,  Komatsu, N., Fujimaki, M.,  Nakashima, H.,  Satoh, K., and   Sakagami, H.:

              Diverse biological activity of moxa extact and smoke.,

              In Vivo, 15; 249-254, 2001.

181.       Motohashi, N.,  Shirataki, Y., Kawase, M.,  Tani, S., Sakagami, H.,    Satoh, K.,  Kurihara, T., Nakashima, H.,  Wolfard, K., Miskolci, C. and Molnar, J.:

              Biological activity of kiwifruit peel extracts.,

              Phytotherapy Res., 15; 337-343, 2001.

182.       Tamamura, H., Omagari, A., Hiramatsu, K., Gotoh, K., Kanamoto, T., Xu, Y., Kodama, E., Matsuoka, M., Hattori, T., Yamamoto, N., Nakashima, H.,  Otaka, A.  and  Fujii, N.:             

Development of specific CXCR4 inhibitors possessing high selectivity index as well as complete stability in serum based on an anti-HIV peptide T140.,

              Bioorg. Med. Chem. Lett., 11; 1897-1902, 2001.

183.       Tamamura, H., Omagari, A., Hiramatsu, K., Kanamoto, T., Gotoh, K.,  Kanbara, K., Yamamoto, N., Nakashima, H., Otaka, A.  and  Fujii, N.: Synthesis and evaluation of bifunctional anti-HIV agents based on  specific      CXCR4 antagonists-AZT conjugation.,

              Bioorg. Med. Chem., 9; 2179-2187, 2001.

184.       Nakashima, H.:

              Biological activity of Feijoa peel extracts.,

The Progress Report of the 1999 Survey of The Research Project "Social Homeostasis of Small Islands in An Island-zone"  Kagoshima University Research Center for Pacific Islands,  Occasional Papers, 34; 169-175, 2001.*

185.       Kawase, M.,  Motohashi, N., Sakagami, H., Kanamoto, T.,  Nakashima, H., Ferenczy, L., Wolfard, K., Miskolci, C.  and  Molnar, J.:      

              Antimicrobial activity of trifluoromethyl ketones and their synergism with    promethazine,

              Antimicrobial  Agents,18; 161-165, 2001.

186.       Shirataki, Y., Tani, S., Sakagami, H., Nakashima, H., Gotoh, K.,  and  Motohashi, N. :

              Relationship between cytotoxic activity and radical intensity of isoflavones from Sophora

              speciesn.,

              Anticancer Res., 21; 2643-2648, 2001.

187.              Motohashi, N., Kurihara, T., Wakabayashi, H., Yaji, M., Mucsi, I., Molnar, J., Maruyama, S., Sakagami, H., Nakashima, H., Tani, S., Shirataki, Y. and Kawase, M.:

Biological activity of a fruit vegetable, “Anastasia Green”, a species of sweet pepper.,

In Vivo, 15; 437-442, 2001.

188.       Shirataki, Y.,  Motohashi, N.,  Tani, S.,  Sunaga, K.,  Sakagami, H.,  Satoh, K.,  Nakashima, H., Kanamoto, T., Wolfard, K. and Molnar, J. :

              Antioxidative activity of Allium victorialis L.extracts.,

              Anticancer Res., 21; 3331-3340, 2001.

163.       Satoh, K., Sakagami, H., Ida, Y., Komatsu, N., Nakashima, H., Kanbara, K., Gupta, M., Sarma, D.N. and Mitra, K.:

Antimicrobial and radical modulation activity of AV-07, a poly-herbal formula.,

              In Vivo, 14; 351-356, 2000.

164.       Motohashi, N., Kawase, M., Saito, S., Kurihara, T., Satoh, K., Nakashima, H., Premanathan, M., Arakaki, R., Sakagami, H. and Molnar, J.:

              Synthesis and biological activity of N-acylphenothiazines.,

              Antimicrob. Agents Chemother.,14; 203-207, 2000.

165.       Gotoh, K., Izumi, H., Kanamoto, T., Tamada, Y. and Nakashima, H.:

Sulfated fibroin, a novel sulfated peptide derived from silk, inhibits human immunodeficiency virus replication in vitro.,

              Biosci. Biotechnol. Biochem., 64; 1664-1670, 2000.

166.       Fukai, T., Sakagami, H., Toguchi, M., Takayama, F., Iwakura, I., Atsumi, T., Ueha, T., Nakashima, H.,  and Nomura, T.:

Cytotoxic avtivity of low molecural weight polyphenols against human oral tumor cell lines.,                              

              Anticancer Res., 20; 2525-2536, 2000.

167.       Tamamura, H., Omagari, A., Oishi, S.,  Kanamoto, T., Yamamoto, N.,  Peiper, S.C., Nakashima, H.,  Otaka, A. and Fujii, N.:

Pharmacophore identification of a specific CXCR4 inhibitor, T140,  leads to development of effective  anti-HIV agents with very high selectivity indexes.,

              Bioorg. Med. Chem. Lett., 10; 2633-2637, 2000.

168.       Motohashi, N.,  Kawase, M.,  Shirataki, Y.,Tani, S., Sakagami, H.,  Kurihara, T.,   Nakashima, H.,  Wolfard, K., Miucsi,L.,  Varga, A.  and Molnar, J.:

              Biological activity of Feijoa peel extracts.,

              Anticancer Res., 20; 4323-4330, 2000.

146.       Arakaki, R., Tamamura, H., Premanathan, M., Kanbara, K., Ramanan, S., Mochizuki, K., Baba, M., Fujii, N. and Nakashima, H.: 

T134, a small molecule CXCR4 inhibitor, has no cross drug-resistance with AMD3100, a CXCR4 antagonist with a different structure.,

              J. Virol., 73(2); 1719-1723, 1999.

147.       Xu, Y., Tamamura, H., Arakaki, R.,  Nakashima, H.,  Zhang, X., Fujii, N., Uchiyama, T. and Hattori, T.:

Marked increase in anti-HIV activity, as well as inhibitory activity against HIV entry mediated by CXCR4, linked to enhancement of the binding ability of tachyplesin analogs to CXCR4.,

              AIDS  Res.  Human  Retroviruses, 15(5); 419-427, 1999.

148.       Arakaki, N., Kajihara, T., Arakaki, R., Ohnishi, T., Kazi, J. A., Nakashima, H. and Daikuhara, Y.:

Involvement of oxidative stress in tumor cytotoxic activity of hepatocyte growth       factor/scatter factor.,

              J. Biol. Chem., 274(19); 13541-13546, 1999.

149.       Yoshida, T., Akasaka, T., Choi, Y., Hattori, K., Yu, B., Mimura, T., Kaneko, Y., Nakashima, H., Aragaki, R., Premanathan, M., Yamamoto, N. and Uryu, T.:

Synthesis of polymethacrylate derivatives having sulfated malthoheptaose  side chains with anti-HIV activites.,

              J. Polymer Sience, 37; 789-800, 1999.

150.       Yasukawa, M., Hasegawa, A., Sakai, I., Ohminami, H., Arai, J., Kaneko, S., Yakushijin, Y., Maeyama, K.,  Nakashima, H., Arakaki, R. and Fujita, S.:

Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and  HHV-7.,

              J. Immunol., 162; 5417-5422, 1999.

151.       Premanathan, M., Kathiresan, K. and  Nakashima, H.:

              Mangrove Halophytes:  a source of antiviral substances.,

              South Pacific  Study,19(1-2); 49-57, 1999. 

152.       Meta, A., Torigoe, N.,  Ito, Y., Arakaki,  R.,  Nakashima, H. and  Sugimura, K.:     

              Peptide-motif analysis of phage clones selected by anti-CCR5 monoclonal antibody

              (2D7).,

Peptide Scienece 1998: (Ed. by M. Kondo),  pp 489-492.  Protein Research, 1999.

153.       Satoh, K., Kihara, T., Ida, Y., Sakagami, H., Koyama, N., Premanathan, M., Arakaki, R.,  Nakashima, H., Komatsu, N., Fujimaki, M., Misawa, Y. and Hata, N.:

Radical modulation activity of pine cone extracts of Pinus elliottii var. Elliottii.

              Anticancer Res., 19(1A); 357-364, 1999.

154.       Motohashi, N., Kawase, M., Kurihara, T., Shirataki, Y., Kamata, K.,  Nakashima, H., Premanathan, M.,  Arakaki, R.,  Kanbara, K.,  Satoh, K.,  Sakagami, H., Saito, S. and Nakamura, T.:                                   

Relationship between radical intensity and biological activity of cacao husk extracts.

              Anticancer Res., 19(2A); 1125-9, 1999.

155.       Katsuraya, K., Nakashima, H., Yamamoto. N.  and  Uryu, T.:

Synthesis of sulfated oligosaccharide glycosides having high anti-HIV activity          and the relationship between activity and chemical structure.

              Carbohydrate  Res ., 315(3-4); 234-242, 1999.

156.       Premanathan, M., Kathiresan, Yamamoto, N. and  Nakashima, H.:

In vitro anti-human immunodeficiency virus activity of polysaccharide from Rizophora mucronata Poir.,

              Biosci. Biotechnol. Biochem., 63(7); 1187-1191, 1999.

157.       Borjihan, G.,  Katsuraya, K.,  Nakashima, H.   and   Uryu, T.:

              Synthesis and anti-HIV activity of  sulfated polysaccharides containing acetamido

              groups.,

              Sen'i Gakkaishi, 55(7); 323-330, 1999. 

158.       Premanathan, M., Arakaki, R., Izumi, H., Kathiresan, K., Nakano, M., Yamamoto, N. and Nakashima, H.:

Antiviral properties of a mangrove plant, Rizophora apiculata Blume, against           human immunodeficiency virus.,

              Antiviral Res., 44; 113-122, 1999.

159.               Gao, Y., Katsuraya, K., Kaneko, Y., Mimura, T.,  Nakashima, H. and Uryu, T.: 

Synthesis, enzymatic hydrolysis, and anti-HIV activity of AZT-spacer-curdlan sulfate.,                                       

Macromolecules,  32; 8391-8324,  1999.

160.       Katsuraya, K., Jeon, K-J,  Nakashima, H. and Uryu, T.:   

              NMR studies on structure and action mechanism of sulfated dodecyl laminaripentaosidewith high anti-human immunodeficiency virus activity.,

              Polymer Journal, 31; 924-928, 1999.  

161.       Sakagami, H., Satoh, K., Ida, Y., Koyama, N., Premanathan, M., Arakaki, R.,        Nakashima, H., Hatano, T., Okuda, T. and Yoshida, T.: 

Induction of apoptosis and anti-HIV activity by tannin-   and lignin-related substances.,

Basic Life Sci  pp 595-611.  Plant Polyphenols 2: Chemist.ry, Biology,  Pharmacology, Ecology,  (Ed. by Gross et al.), Kluwer Academic/Plenum Publishers, New York, 1999.*

162.       Meta, A., Torigoe, N.,  Ito, Y., Arakaki,  R.,  Nakashima, H.  and  Sugimura, K.:     

              Inhibition of M-tropic HIV-1 infection by the fd phage-gene 3 protein with MIP-1a-

              binding activity.,

              Molecular Immunol., 36;1249-1254, 1999.

133.       Gao, Y., Katsuraya, K., Kaneko, Y., Nakashima, H. and Uryu, T.: 

              Synthesis of azidothymidine-bound  curdlan sulfate with anti-human immunodeficiency

              virus activity in vitro.,                                         

              Polymer J., 30; 31-36, 1998.

134.       Hattori, K., Yoshida, T., Nakashima, H., Premanathan, M., Aragaki, R.,  Mimura, T., Kaneko, Y., Yamamoto, N. and  Uryu, T.:

              Synthesis of sulfonated amino-polysaccharides having anti-HIV and blood   anticoagulant

              activities.,

              Carbohydrate Res., 312(1-2); 1-8, 1998.   

135.               Tamamura, H., Ishihara, T., Oyake, H.,  Imai, M., Otaka, A., Ibuka, T., Arakaki, R., Nakashima, H.,  Murakami, T., Waki, M., Matsumoto, A.,  Yamamoto, N. and Fujii, N.:                                                        

Convenient one-pot synthesis of cystine-containing peptides using the trimethylsilyl chroride-dimethyl sulfoxide/trifluoroacetic acid system and its application to the synthesis of bifunctional anti-HIV compounds.,

              J. Chem. Soc., Perkin Trans., 1; 495-500, 1998.

136.       Tamamura, H.,  Arakaki, R., Funakoshi, H., Imai, M., Otaka, A., Ibuka, T., Nakashima, H.,  Murakami, T., Waki, M., Matsumoto, A.,  Yamamoto, N. and Fujii, N.:  

Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22([Tyr5,12, Lys7]-polyphemusin II).,

              Bioorganic Med. Chemist., 6; 231-238, 1998.

137.       Tamamura, H., Waki, M., Imai, M., Otaka, A., Ibuka, T., Waki, K., Miyamoto, K., Matsumoto, A.,  Murakami, T., Nakashima, H., Yamamoto, N. and Fujii, N.:

              Downsizing of an HIV-cell fusion inhibiotor, T22 ([Tyr5,12, Lys7]- polyphemusin II),

              with the maintenance of anti-HIV activity and solution structure.,

              Bioorganic Med. Chemist., 6; 473-479, 1998.

138.       Nishimura, S., Kai, H., Shinada, K., Yoshida, T., Tokura, S., Kurita, K., Nakashima, H., Yamamoto, N. and Uryu, T.:

              Regioselectivity syntheses of sulfated polysaccharides: specific anti-HIV-1 activity of

              novel chitin sulfates.,

              Carbohydrate Res., 306; 427-433, 1998. 

139.       Sakagami, H., Kashimata, M., Toguchi, M., Satoh, K., Odanaka, Y., Ida, Y.,         Premanathan, M., Arakaki, R., Kathiresan, K., Nakashima, H., Komatsu, N., Fujimaki, M. and Yoshihara, M.:

Radical modulation activity of lignins from a Mangrove plant, Ceriops decandra  (Griff.) Ding Hou.,

              In  Vivo,  12;  327-332,  1998.

140.       Tamamura, H., Imai, M., Ishihara, T., Masuda, M., Funakoshi, H. Oyake, H.,  Murakami, T.,          Arakaki, R., Nakashima, H., Otaka, A., Ibuka, T., Waki, M., Matsumoto, A., Yamamoto, N. and Fujii, N.:

Pharmacophore identification of a chemokine receptor (CXCR4)   antagonist, T22 ([Tyr5,12, Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV infection.,

              Bioorganic Med. Chemist.,   6; 1033-1041,  1998.

141.       Premanathan,  M.,  Arakaki,  R.,  Ramanan, S., Jinno, S.,  Baba, M.,  Yamashita, S. and Nakashima, H.:             

3-(5-Dimethylamino-1-naphthalenesulfonyl)-2-(3-pyridyl) thiazolidine (YHI-1) selectively inhibits human immunodeficiency virus type 1.,

              Antiviral Chemist. Chemother., 9(5); 423-430, 1998.       

142.       Meta, A., Torigoe, N.,  Ito, Y., Arakaki,  R.,  Nakashima, H.   and  Sugimura, K.:     

Peptide-motif analysis of phage clones recognized by anti-CCR5 monoclonal antibody (2D7).

pp 1475-1479.  In 10th International Congress of IMMUNOLOGY ,     New Delhi, India  (Ed. by Talwar, G.P., Nath, I, Ganguly, N.K. and      Rao, K.V.S.),    Monduzzi Editore, International Proceedings Division,  Bologna, Italy. 1998.* 

143.       Arakaki, R., Sugawara, S.,  Nakashima, H., Kotani, S. and Takada, H.:

A lipoteichoic acid fraction of Enterococcus hirae activates cultured human monocytic cells via a CD14-independent pathway to promote cytokine production, and the activity is inhibited by serum components.

              FEMS Immunol. Med. Microbiol., 22(4); 283-291, 1998.

144.       Tamamura, H., Xu, Y., Hattori, T., Zhang, X.,  Arakaki, R., Kanbara, K.,          Omagari, A., Otaka, A.,  Ibuka, T., Yamamoto, N.,  Nakashima, H. and Fujii, N.:           

A low molecular weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.,

              Biochem. Biophys. Res. Commun.,  253(3);   877-882, 1998.

145.       Abe, T., Hatta, T., Takai, K., Nakashima, H., Yokota, T. and  Takaku H.:

Inhibition of influenza virus replication by phosphorothioate and liposomally  endocapsulated oligonucleotides.,

125.       Premanathan, M., Nakashima, H.,  Igarashi, R.,  Mizushima, Y.  and Yamada, K.:

Lecithinized superoxide dismutase : an inhibitor of human immunodeficiency  virus  replication.

              AIDS Res. Human Retroviruses, 13; 283-290, 1997.

126.       Soung-Choi, Y., Won-Kang, B., Lu, R., Osawa, M., Hattori, K., Yoshida, T., Mimura, T., Kaneko, Y.,  Nakashima, H., Yamamoto, N.  and Uryu, T.:    

Synthesis of sulfated deoxy-ribofuranans having selective anti-AIDS virus activity by ring-opening copolymerization of 1,4-anhydro ribose derivatives.,

              Polymer Journal, 29; 374-379, 1997.

127.       Nakano, M., , Itoh, Y., Mizuno, T. and Nakashima, H.: 

              Polysaccharide from Aspalatus    linearis  with strong anti-HIV activity.,

              Biosci. Biotech. Biochem., 61; 267-271, 1997.

128.       Tanaka, H., Matsuzaki, K.,  Nakashima, H.,  Ogino, T., Matsumoto, A., Ikeda, H., Woodruff, B. and  Omura, S.:    

Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp.I.  Taxonomy,  fermentation,  isolation,  and  physico-chemical properties and biological activities.,

              J. Antibiotics, 50; 58-65, 1997.

129.       Gao, Y., Fukuda, A., Katsuraya, K., Kaneko, Y., Mimura, T., Nakashima, H. and Uryu, T.:             

              Synthesis of regioselective substituted curdlan sulfates with medium molecular weights and their specific anti-HIV-1 activities.,

              Macromolecules, 30; 3224-3228, 1997. 

130.       Nakano, M., Nakashima, H.  and  Itoh, Y.: 

Anti-human immunodeficiency virus activity of oligosaccharides from rooibos            tea (Aspalathus linearis) extracts in vitro.,

              Leukemia,  Suppl 3; 128-130, 1997.

131.       Uryu, T.,  Katsuraya, K., and Nakashima, H.: 

Synthesis of sulfated alkyl origosaccharides with potent anti-HIV-1 activity.,

              Macromol. Symp.,  120;  147-158,  1997.*

132.       Premanathan, M., Kathiresan, M., Nakashima, H. and Yamamoto, N.:

In vitro anti-human immunodeficiency virus activity of some Indian medicinal  plants.,

              Tropical Biomedicine,  14;  65-69,  1997.

114.       Choi, Y.S., Yoshida, T.,  Mimura, T., Kaneko, Y.,   Nakashima, H.,  Yamamoto, N. and Uryu, T.: 

Synthesis of sulfates octadecyl ribo-oligosaccharides with potent anti-AIDS              virus activity by ring-opening polymerization of a 1,4-anhydroribose derivative.,

              Carbohydrate Res., 282; 113-123, 1996.

115.       Nakashima, H., Ichiyama, K., Inazawa. K.,  Ito, M., Hayashi, H.,    Nishihara, Y., Tsujii, E. and Kino, T.: 

              FR901724, a novel anti-human immunodeficiency virus (HIV) peptide produced by

              Streptomyces shows synergistic antivial activities with HIV protease inhibitor and 2',3'-

              dideoxynucleosides.,

              Biol. Pharm. Bull., 19；405-412, 1996.

116.       Hosono, K.,  Kuwasaki, T., Inagawa, T., Takai, K.,  Nakashima, H.,    Saito, T., Yamamoto, N.,   and  Takaku, H.:    

Properties and anti-HIV activity of hairpin antisense oligonucleotides containing 2'-methoxynucleosides with base-pairing in the stem region   at the 3'-end.,

              Antiviral Chem. Chemother., 7; 86-93, 1996.

117.        Nakashima, H., Ichiyama, K., Hirayama, F., Uchino, K., Saitoh, T., Ueki, M.,  Ito, M., Yamamoto, N. and Ogawara, H.:

Sulfated pentagalloyl  glucose (Y-ART-3) inhibits HIV replication and cytopathic effects in vitro, and reduces HIV infection in hu-PBL-SCID  mice.,

              Antiviral Res., 30; 95-108, 1996.

118.       Kim, S-G.,  Nakashima, H., Shoji, Y., Inagawa, T., Yamamoto, N.,   Kinzuka, Y.,  Takai, K. and Takaku, H.:

5'-Linked lipid-oligodeoxyribonucleotide derivatives as inhibitors of human               immunodeficiency virus replication.,

              Bioorganic Medicinal Chemistry, 4; 603-608, 1996.

119.        Premanathan, M., Nakashima, H., Kathiresan, K., Rajendran, N. and Yamamoto, N.: 

              In vitro anti-human immunodeficiency virus activity of mangrove plants.,

              Indian J. Med. Res., 103;  276-279, 1996.

120.       Katsuraya, K., Inazawa, K., Nakashima, H.  and Uryu, T.:

              Synthesis of sulfated alkyl oligosaccharides with high anti-HIV activity. Defendence on

              the alkyl group and the olysaccharide chain.,

In  Biomedical Functions and Biotechnology of Natural and Artificial Polymers  (Ed. by Yalpani, M.), pp195-205, ATL Press. Inc.,  IL., 1996.*

121.       Waki, M., Waki. K., Miyamoto, K., Matsumoto, A., Tamamura, H., Fujii, N., Murakami, T.,  Nakashima, H. and Yamamoto, N.:

              Design, synthesis and activity of shortened analogs of an anti-HIV peptide, T22.,

Peptide Chemistry 1995: N. Nishi (ed.) Protein Research Foundation, Osaka, pp 233-236,  1996.*

122.       Waki, M., Waki. K., Miyamoto, K., Matsumoto, A., Tamamura, H., Fujii, N., Murakami, T.,  Nakashima, H.  and  Yamamoto, N.:

Molecular size of an anti-HIV peptide, T22, can bereduced without loss of the activity.,

              Chemistry Letters, 571-572, 1996.

123.       Kuwasaki, T., Hosono, K., Takai, T., Ushijima, K., Nakashima, H., Saito, T., Yamamoto, N. and Takaku, H.:

              Hairpin antisense oligonucleotides containing 2'-methoxy nucleosides with base-pairing in

              the stem region at the 3'-end: penetration, localization, and anti-HIV activity.,

              Biochem. Biophys. Res. Commun., 228; 623-631, 1996.

124.       Shoji, Y., Nakashima, H., Iwatani, N., Norimatsu, M., Shimada, J. and Mizushima, Y.: 

              Anti-HIV activity of phosphorothioate oligodeoxynucleotides containing consecutive G

              sequences.,

              Int. J. Immunotherapy,  XII; 1-9, 1996.

104.       Tamamura, H., Otaka, A., Takada, W., Terakawa, Y., Yoshizawa, H.,  Masuda, M., Ibuka, T., Murakami, T., Nakashima, H., Waki, M.,    Matsumoto, A., Yamamoto, N. and Fujii, N.:

Solution-phase synthesis of an anti-human immunodeficiency virus peptide,T22 ([Tyr5,12, Lys7]-polyphemusin II),  and  the  modification  of  Trp  by  the p-methoxybenzyl group of Cys during trimethylsilyl trifluorometane sulfonate deprotection.,

              Chem. Pharm. Bull., 43;  12-18, 1995. 

105.       Kim, S-G., Hatta, T., Tsukahara, S.,  Nakashima, H., Yamamoto, N., Shoji, Y., Takai, K. and Takaku, H.:

Antiviral effect of phosphorothioate oligodeoxyribonucleotides complementary         to human immunodeficiency virus.,

              Bioorganic Medicinal Chemistry, 3; 49-54, 1995.

106.       Mucsi, I., Molnar, J., Burian, K., Beladi, I., Sakagami, H., Nakashima, H., Inazawa, K. and Motohashi, N.:   

Antiviral  activity  of  phenothiazine and benzo[a ]phenothiazine derivatives.,

pp 347-356. In  Biological and chemical aspects of thiazines and analogs   (Ed. by Barbe, J., Keyzer, H. and Soyfer, J.C.),  Enlight Associates,      San Gabriel, California.  1995.*

107.       Nakashima, H.,  Inazawa, K., Ichiyama, K., Ito, M.,  Ikushima, N., Shoji, T.,            Katsuraya, K.,  Uryu, T.,  Yamamoto, N., Juodawlkis, A.S. and     Schinazi, R.F.: 

Sulfated alkyl oligosaccharides inhibit human immunodeficiency virus   in vitro       and provide sustained drug levels in mammals.,

               Antiviral Chem. Chemother.,  6;  271-280, 1995.

108.      Osada, A.,  Nakashima, H., Furue, M., and Tamaki, K.: 

Up-regulation of CD44 expression by  tumor necrosis factor-a  is  neutralized by Interleukin-10  in Langelhans cells.,

              J. Invest. Dermatol.,  105;  124-127, 1995.

109.               Hatta, T.,  Takai, K., Yokoyama, S., Nakashima, H.,  Yamamoto, N. and Takaku, H.:                                             

Phosophorothioate oligonucleotides block reverse transcription by the RNaseH activity associated with the HIV-1 polymerase.,

              Biochem. Biophys. Res. Commun.,  211;  1041-1046, 1995.

110.               Yamakawa, H., Ishibashi, T.,  Nakashima, H., Yamamoto, N., Takai, K. and Takaku, H.:                                           

              Properties and anti-HIV activity of circular sense and antisense oligonucleotides.,

              Nucleosides & Nucleotides,  14;  1149-1152, 1995.

111.               Katsuraya, K.,  Shibuya, T.,  Inazawa, K.,  Nakashima, H.,  Yamamoto, N. and Uryu, T.:                                    

Synthesis of sulfated alkyl malto-oligosaccharides with potent inhibitory effects        on AIDS virus infection.,

              Macromolecules,  28;  6697-6700, 1995.

112.        Yoshida, T.,  Yasuda, Y.,  Mimura, T., Kaneko, Y.,   Nakashima, H.,  Yamamoto, N. and Uryu, T.: 

Synthesis of curdlan sulfates having  inhibitory effects in vitro against AIDS viruses HIV-1 and HIV-2.,

              Carbohydrate Res.,  276;  425-436, 1995.

113.       Shang, H.,  Miyakawa, Y.,  Sasaki, T.,  Nakashima, H.  and  Ito, M.: 

Suppression of HIV-1 reverse transcriptase activity by culture supernatants of         Mycoplasmas.,

              Microbiol. Immunol,   39;  987-993, 1995.

90.         Nakashima, H., Ohshiro, Y., Miyano, N., Yamamoto, N., Ichikawa, S.,  Kondo, H., Takeda, M. and  Sakagami, H.:

Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by sulfated paramylon and 3'-azido-2',3'-dideoxythymidine  (AZT).,

              Letters in Applied Microbiology, 18; 24-26, 1994. 

91.         Otake, T., Schols,D., Witvrouw, M., Naesens, L., Nakashima, H., Moriya, T., Kunita, H.,  Matsumoto, K., Ueba, N. and De Clercq, E.:

              Modified cyclodextrin sulfates (m CDS)   have potent inhibitory activity against HIV and high oral bioavailability.,

              Antiviral Chem. Chemother.,   5; 155-161, 1994.

92.         Katsuraya, K., Ikushima, N., Takahashi, N., Shoji, T., Nakashima, H., Yamamoto, N., Yoshida, T. and Uryu, T.: 

Synthesis of sulfated alkyl malto- and laminara-oligosaccharides    with potent inhibitory effects on AIDS virus infection.,

              Carbohydrate Res.,   260;  51-61, 1994.

93.                  Jagodzinski, P.P., Wiaderkiewicz, R.,  Kurzawski, G., Kloczewiak, M., Nakashima,

              H.,  Hyjek, E., Yamamoto, N., Uryu, T., Kaneko, Y.,     Posner, M. R.  and  Kozbor,

              D.:                                   

Mechanism of the inhibitory effect of  curdlan sulfate on HIV-1 infection   in vitro.,

              Virology,   202;  735-745, 1994.

94.         Yoshida, T., Wu, C.,  Song, L., Uryu, T., Kaneko, Y., Mimura, T.,  Nakashima, H. and Yamamoto, N.:

Synthesis of cellulose-type polyriboses and their branchedsulfates with   anti-AIDS virus activity by selective ring-opening copolymerization of 1,4-anhydro-a-D-ribopyranose derivatives.,

              Macromolecules,  27;  4422-4428, 1994.

95.         Miyano-Kurosaki, N,   Nakashimma, H.,   Ichiyama, K.,   Inazawa, K.,  Tabata, H., Tanabe, H., Ohnishi, K., Mizusawa, H., Ohshiro, Y., and Yamamoto, N.:

              A  novel assay system for anti-human immuno-deficiency  virus type 1 (HIV-1) activity using a subclone fo a monocytic cell line U937.,

              Microbiol. Immunol, 38;  813-818, 1994.

96.         Yoshida, T.,  Yasuda, Y.,  Uryu, T.,   Nakashima, H.,  Yamamoto, N.,  Mimura, T.,  and Kaneko, Y.:

Synthesis and in vitro inhibitory effect of L-glycosyl-branched curdlan sulfates on AIDS virus infection.,

              Macromolecules,  27;  6272-6276, 1994.

97.                 Katsuraya, K., Shoji, T., Inazawa, K.,  Nakashima, H.,  Yamamoto, N. and Uryu, T.: 

Synthesis of sulfated alkyl laminara-oligosaccharides having potent anti-HIV activity and the relationship between structure and biological activities.,

              Macromolecules,  27;  6695-6699, 1994.

98.         Nakashima, H., Shoji, Y., Kim, S-G.,  Shimada, J., Mizushima, Y., Ito, M., Yamamoto, N. and Takaku, H.:

Anti-human immunodeficiency virus type 1 activity of phosphorothioate analogs       of oligodeoxynucleotides; penetration and localization of oligodeoxynucleotides            in HIV-1-infected MOLT-4 cells.,

              Nucleic Acids Res.,  22;  5004-5010, 1994.

99.         Tamamura, H.,   Murakami, T.,  Masuda, M.,  Otaka, A.,   Takada, W.,    Ibuka, T., Nakashima, H.,  Waki, M.,  Matsumoto, A.,  Yamamoto, N.  and   Fujii, N.:

              Structure-activity relationships of an anti-HIV peptide, T22.,

              Biochem. Biophys. Res. Commun.,  205; 1729-1735, 1994.

100.       Aoki, K., Nakashima, H., Shiokawa, D., Hattori, T., Ni-imi, E., Tanimoto, Y., Maruta, H., Uchiumi, F., Yamamoto, N., Kochi, M., and Tanuma, S.: 

Sodium benzylideneascorbate induces apoptosis in HIV-replicating U1 cells.,

              FEBS letters,   351; 105-108, 1994.  

101.       Otaka, A., Tamamura, H.,  Terakawa, Y.,  Masuda, M., Koide, T.,  Murakami, T., Nakashima, H., Matsuzaki, K., Miyajima, K., Ibuka, T.,   Waki, M., Matsumoto, A., Yamamoto, N. and Fujii, N.:   

              Molecular  parameters  for the  anti-human     immunodeficiency virus activity of T22([Tyr5,12, Lys7]-polyphemusin II).,

              Biol. Pharm. Bull.,    17;  1669-1672, 1994.

102.       Katsuraya, K., Shibuya, T., Inazawa, K., Nakashima, H. and Uryu, T.: 

Synthesis of sulfated alkyul oligosaccharides having potent anti-HIV activity            and relationship between stracture and biological activities.,

              Proc. Int. Symp. Fiber Sci. Tech.,  421, 1994.

103.       Kanbara,K.,  Nagai, K., Nakashima, H., Yamamoto, N., Torrence, P.F.,  Suhadolink R.J. and  Takaku, H.:

The relationship between conformation and biological activity of       8-substituted analogues of 2',5'-oligoadenylates.,

              Antiviral Chem. Chemother.,  5; 1-5, 1994.

79.         Yamamoto, N., Schols, D., De Clercq, E., Debyser, Z., Pauwels, R.,    Balzarini, J., Nakashima, H.,  Baba, M., Hosoya, M., Snoeck, R., Neyts, J., Andrei, G., Murrer, B. A., Theobald, B., Bossard, G., Henson, G., Abrams, M. and Picker, D.:

Mechanism of anti-Human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral gents.,

              Molecular Pharmacology, 42; 1109-1117, 1993. 

80.         Uryu, T., Kaneko, Y., Yoshida, T., Mihara, R., Shoji, T., Katsuraya, K., Nakashima, H.  and Yamamoto, N.:

Synthesis of anti-HIV active sulfated olysaccharides and sulfated alkyl oligosaccharides.,

In  Carbohydrates and Carbohydrate Polymers, Analysis, Biotechnology, Modification, Antiviral, Biomedical and Other Applications,  Chapter 10  (Ed. by Yalpani, M.),    pp101-115,      

              ATL Press. Inc.,  IL.,  1993.* 

81.         Nakashima, H., Oshiro, Y. and Yamamoto, N.:

Pharmacological control of human immnodeficiency virus (HIV) infection.,

              J. Viral Diseases, 1; 40-52, 1993.*

82.         Koizumi, N., Sakagami, H., Utsumi, A., Fujinaga,S., Takeda, M., Asano, K., Sugawara, I., Ichikawa, S., Kondo, H., Mori, S., Miyatake, K., Nakano, Y., Nakashima, H., Murakami, T., Miyano, N. and Yamamoto, N.: 

Anti-HIV (human immunodeficiency virus) activity of sulfated paramylon.,

              Antiviral Res., 21; 1-14, 1993.

83.         Tamamura, H.,  Kuroda, M.,  Masuda, M.,  Otaka, A.,  Funakoshi, S.,   Nakashima, H.,  Yamamoto, N,  Waki, M., Matsumoto, A., Lancelin, J. M., Kohda, D, Tate, S., Inagaki, F. and Fujii, N.:

A comparative study of the solution  structures  of  tachyplesin  I  and   a novel  anti-HIV  synthetic  peptide,  T22 ([Tyr 5,12,Lys7]-polyphemusin II), determined by nuclear magnetic resonance.,

              Biochem Biophys. Acta., 1163; 209-216, 1993.

84.         Nakashima, H., Yamamoto, N., Masuda, M. and Fujii, N.: 

              Defensins inhibit HIV replication   in vitro.,

              AIDS, 7; 1129, 1993.

85.         Shimizu, N., Naoe, T., Kawazoe, Y., Sakagami, H., Nakashima, H.,  Murakami, T. and Yamamoto, N.:

Lingnified materials as medicinal resources. VI. anti-HIV activity of dehydrogenation polymer of p-coumaric acid a synthetic lignin, in a quasi-in-vivo assay system as an intermediary step to clinical trials.,

              Biol. Pharm. Bull., 16; 434-436, 1993. 

86.         Kim, S-G., Kanbara, K, Nakashima, H., Yamamoto,N., Murakami, K. and Takaku, H.:

Anti-HIV activities and physicochemical properties of phosphorothioate analogues cmplementary to HIV sequences.,

              Bioorganic Medicinal Chemistry Lett., 13; 1223-1228, 1993.

87.                   Hatta,T., Kim,S-G., Nakashima,H., Yamamoto,N., Sakamoto,K., Yokoyama,S. and Takaku,H.: 

Mechanisms of the inhibition of reverse transcription by unmodified and modified antisense oligonucleotides.,

              FEBS, 330; 161-164, 1993.

88.        Yoshida,T., Nakashima,H., Yamamoto,N. and Uryu,T.:

Anti-AIDS virus activity in vitro of dextran sulfates obtained by sulfation of synthetic and natural dextrans.,

              Polymer Journal, 25; 1069-1077, 1993.

89.         Nagai, K., Kanbara, K., Nakashima, H., Yamamoto, N., Torrence, P. F., Suhadolnik, R. J. and Takaku, H.:

Characteriztin and biologicl activity of 8-substituted analogues of 2',5'-oligoadenylates.,

              Biochem. Biophys. Acta, 1156; 321-326, 1933.

64.         Sakagami, H., Yoshihara, M., Fujimaki, M., Wada, C., Komatsu, N., Nakashima, H., Murakami, T. and Yamamoto, N.:

              Effect of pine seed shell extract on microbial and viral infection.,

              In Vivo, 6; 13-16, 1992.

65.         Nakashima, H., Murakami, T., Yamamoto, N., Sakagami, H., Tanuma, S., Hatano, T., Yoshida, T. and Okuda, T.:

Inhibition of human immunodeficiency viral replication by tannins and related compounds.,

              Antiviral Res.,18; 91-103, 1992.

66.         De Clercq, E., Yamamoto, N., Pauwels, R., Baba, M., Schols, D., 　　Nakashima, H., Balzarini, J., Debyser, Z., Murrer, B. A., Schwartz, D., Thornton, d., Bridger, G., Fricker, S., Henson, S., Abrams, M. and Picker, D.:

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.,

              Proc. Natl. Acad. Sci. USA, 89; 5289-5290, 1992. 

67.         Sakagami, H., Nakashima, H., Murakami, T., Yamamoto, N., Hatano, T., Yoshida, T.  and   Okuda, T.: 

Structures and activities of tannins in crude drugs (4) - effects on phagocytes   and viruses,

              J. Pharmacobio-Dyn., 15 suppl.; 5, 1992.

68.         Toukairin, T., Uchino, K., Mizuno, T., Nakashima, H., Yamamoto, N. and Ogawara, H.:

New substances against human immunodeficiency virus; Sulfated 5'-nucleotidese inhibitory polyphenols.,

              Chem. Pharm. Bull., 40; 802-804, 1992.

69.         Nakashima, H.,  Murakami, T.,  Yamamoto, N.,  Naoe, T.,  Kawazoe, Y.,  Konno, K. and Sakagami, H.:    

Lignified materials as medicinal resources. V. Anti-HIV (human   immunodeficiency virus) activity of some synthetic lignins.,

              Chem. Pharm. Bull.,  40; 2102-2105, 1992.

70.         Hosaka, H., Suzuki, Y., Nakamura, H., Funakoshi, H., Nakashima, H., Yamamoto, N. and Takaku, H.:

Synthesis of ologodeoxyribonucleotideanalogues by use of deoxyribonucleoside-3'-yl O-bis (1,1,1,3,3,3-hexafluoro-2-propyl) phosphites as new key intermediates.,

              Nucleosides & Nucleotides, 11; 669-678, 1992.

71.         Murakami, T., Nakashima,H., Ito, M. and Yamamoto, N.:

              A novel coculture system for evaluating  anti-HIV drugs.,

              AIDS, 6; 1279-1285, 1992.  

72.         Nakashima, H., Masuda, M., Murakami, T., Koyanagi, Y., Matsumoto, A., Fujii, N. and Yamamoto, N.:  

Anti-human immunodeficiency virus activity of a novel synthetic peptide, T22 ([Tyr-5,12, Lys-7] polyphemusin II) : a possible inhibitor of virus-cell fusion.,

              Antimicrob. Agents Chemothr., 36; 1249-1255, 1992.

73.         Manabe, H.,   Sakagami, H.,   Ishizone, H.,   Kusano, H.,   Fujimaki, M.,   Kowada, C., Komatsu, N.,  Nakashima, H., Murakami, T. and Yamamoto, N.:

              Effects of catuaba extracts on microbial and HIV infection.,

              In Vivo, 6; 161-166, 1992.

74.         Uryu, T., Ikushima, N., Katsuraya, K., Shoji, T., Takahashi, N., Yoshida, T., Kanno, K., Nakashima, H. and Yamamoto, N.:

Sulfated alkyl oligosaccharides with potent inhibitory effects on human immunodeficiency virus infection.,

              Biochem. Pharmacol., 43; 2385-2392, 1992.

75.                   Tanabe-Tochikura, A., Nakashima, H., Murakami, T., Tenmyo, O.,  Oki, T.  and  Yamamaoto, N.:

Anti-human immnofeciciency virus (HIV) activity of the novel antiviral antibiotic quartromicins which enhance inhibitory effect of 3'-azido-2',3'-dideoxythymidine (AZT) in vitro.,

              Antiviral Chem. Chemother., 3; 345-349, 1992.

76.         Masuda, M., Nakashima, H., Ueda, T., Naba, H., Ikoma, R., Otaka, A., Terakawa, Y., Tamamura H., Ibuka, T., Murakami, T., Koyanagi, Y., Waki, M., Matsumoto, A., Yamamoto, N., Funakoshi, S. and Fujii, N.:   

A novel anti-HIV synthetic peptide,　T-22 　([Tyr 5,12, Lys 7]-polyphemusin II),

              Biochem. Biophys. Res. Commun., 189; 845-850, 1992. 

77.         Masuda, M., Nakashima, H., Ueda, T., Naba, H., Ikoma, R., Funakoshi, S., Murakami, T., Koyanagi, Y., Yamamoto, N. and Fujii, N.:

              Structure-activity relationships of tachyplesin analogs as anti-HIV agent.,

              J. Pharmacobio-Dyn., 15 suppl.; 90, 1992.

78.         Mizuno, T., Uchino, K.Toukairin, T., Tanabe, A., Nakashima, H., Yamamoti, N. and  Ogawara, H.:

Inhibitory effect of tannic acid sulfate and related sulfats on infectivity, cytopathic effect, and giant cell formation of human immunodeficiency virus.,

              Planta Medica, 58; 535-539, 1992.

54.        Hirabayash, K.,   Iwata, S.,   Matsumoto, I.,   Mori, T.,   Shibata, S.,   Baba, M.,   Ito, M.,   Shigeta, S.,   Nakashima, H.  and  Yamamoto, N.:

              Antiviral activities of Glycyrrhizin and its modified compunds against human immunodeficiency virus type 1 (HIV-1)  and  herpes simplex virus  type 1   (HSV-1)  in vitro.,

              Chem. Pharm. Bull., 39; 112-115, 1991.

55.                   Yamamoto, I., Takayama, K., Honma, K., Gonda, T., Matsuzaki, K., 　Hatanaka, K., Uryu, T., Yoshida, O., Nakashima, H., Yamamoto, N., 　　Kaneko, Y. and Mimura, T.:

Synthesis, structure adn antiviral activity of sulfates of cellulose and its branched derivatives.,

              Carbohydrate Polymers, 14; 53-63, 1991.

56.         Uryu, T., Yoshida, T.., Ikushima, N., Hatanaka, K., Kaneko, Y., Mimura, T., Nakashima, H. and Yamamoto, N.:

Sulfated polysaccharides as a potent and selective inhibitor of AIDS virus infection.,

In   "Polymer Science" Contemporaty Themes  Vol II (Ed.by Sivaram, S.),     pp 989-996.     

              Tata McGraw-Hill Pobulishing Co. Ltd.,  New Delhi, India. 1991.*  

57.        Baba, M., De Clercq, E., Tanaka, H., Ubasawa, M., Takashima, H., Sekiya, K., Nitta, I., Umezu, K., Nakashima, H., Mori, S., Shigeta, S., Walker, R. and Miyasaka, T.:

Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase.,

              Proc. Natl. Acad. Sci. USA, 88; 2356-2360, 1991.

58.         Schols, D., De Clercq, E., Witvrouw, M., Nakashima,H., Snoeck, R., 　　Pauwels, R., Van Schepdael, A. and Claes, P.:

Sulphated cyclodextrins are potent anti-HIV agents acting synergistically with 2',3'-dideoxynucleoside analogues.,

              Antiviral Cehmist. Chemother., 2; 45-53, 1991.

59.        Tanaka, H., Baba, M., Saito, S., Miyasaka, T., Takashima, H., Sekiya, K., Ubasdawa, M., Nitta, I., Walker, R. T., Nakashima, H. and De Clercq, E.:

Specific anti-HIV-1 "Acyclonucleosides" which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy) methyl]-6-(henylthio)-thymine.,

              J. Med. Chem., 34; 1509-1511, 1991.

60.         Otake, T., Miyano, K., Mori, H., Morimoto, M., Ueba, N., Kunita, N., Nakashima, H. and Kurimura, T.:

              Anti-HIV-1 activity of sulfated amphotericin B in vitro.,

              Antiviral Res., 16; 243-266, 1991.

61.         Schramm, H., Nakashima, H., Schramm, W., Wakayama, H. and　　　Yamamoto, N.:

HIV-1 protease in inhibited by peptides derived from the N- and C-termini of HIV-1 protease.,

              Biochem. Biophys. Res. Commun., 179; 847-851, 1991. 

62.         Kim, S-G., Suzuki, Y., Nakashima, H., Yamamoto, N. and Takaku, H.:

Phosphothioate analogues of oligodeoxyribonucleotide;  synthesis and  activity  as inhibitors of  replication of  human immunodeficiency virus.,

              Biochem. Biophys. Res. Commun., 179; 1614-1619, 1991.

63.         Kim, S-G., Suzuki, Y., Nakashima, H., Yamamoto, N. and Takaku, H.:

Synthesis of antisense  oligodeoxyribonucleotides and their anti-HIV activity.,

              Nucleic Acids Res. Sym. Seri.,  25; 103-104, 1991.

48.                   Nakashima, H., Balzarini, J., Pauwels, R., Schols, D., Desmyter, J. and

              De Clercq, E.:     

Anti-HIV-1 activity of antiviral compounds, as quantitated by a focal immunoassay in CD4+ HeLa cells and a plaque assay in MT-4 cells.,

              J. Virol. Methods, 29; 197-208, 1990.

49.         Baba, M., Schols, D., Pauwels, R., Nakashima, H. and De Clercq, E.:

Sulfated polysaccharides as potent inhibitors of HIV-induced syncytium formation: A new strategy towards AIDS chemotherapy.,

              J. Acquired Immune Deficiency Syndromes, 3; 493-499, 1990.

50.                  Yamamoto, I., Takayama, K., Gonda, T., Matsuzaki, K., Hatanaka, K.,

Yoshida, T., Uryu, T., Yoshida, O., Nakashima, H., Yamamoto, N., Kaneko, Y. and Mimura, T.: 

Synthesis, structure and activiral activity of sulfates of curdlan and its branched derivatives.,

              British Polymer Journal, 23; 245-250, 1990.

51.         Baba, M., De Clercq, E., Iida, S., Tanaka, H., Nitta, I., Ubasawa, M., Takashima, H., Sekiya, K., Umezu, K., Nakashima, H., Shigeta, S., Walker, R. T. and Miyasaka, T.: 

Anti-human  Immunodeficiency Virus type 1 activities and pharmacokinetics of novel 6-substituted acyclouridine derivatives.,

              Antimicrob. Agents Chemother., 34; 2358-2363, 1990.

52.         Nakashima, H.:

              Development of anti-human immunodeficiency virus (HIV) agents.,

              Bull. Yamaguchi Med. Sch., 37; 169-180, 1990. 

53.         Suzuki, M., Nakashima, H. and Shinozaki, F.:

Quantitative evaluation of the inactivation of human immunodeficiency virus (HIV) by antiseptics for the oral cavity.,

              Bull. Yamaguchi Med. Sch., 37; 95-100, 1990.

39.                   Shibahara, S., Mukai, S., Morisawa, H., Nakashima, H., Kobayashi, S. and Yamamoto, N.:

Inhibition of human immnodeficiency virus (HIV-1) replication by synthetic oligo-RNA derivatives.,

              Nucleic Acids Res., 17; 239-252, 1989.

40.         Uryu, T., Hatanaka, K., Yoshida, T., Matsuzaki, K., Kaneko, Y., Mimura, T., Nakashima, H.,  Yoshida, O. and Yamamoto, N.:

              Selective synthesis of biological active polysaccharides.,

Proc. Nisshinbo Int. Conf. (Dec. 5, 6 1988) , Elsevier Science Pub., pp 224-231, 1989.*

41.         Nakashima, H., Yoshida, O., Baba, M., De Clercq, E. and Yamamoto, N.:

Anti-HIV acitivity of dextran sulfate as determined under different experimental conditions.,

              Antiviral Res., 11; 233-246, 1989.

42.                   Baba, M., Schols, D., Nakashima, H., Pauwels, R., Parmentier, G.,

              Meijer, D. K. F. and De Clercq, E.:

              Selective activity of several cholic acid derivatives against human I mmunodeficiency

              virus replication in vitro.,

              J. Acquired Immune Deficiency Syndromes, 2; 264-271, 1989. 

43.                   Hatanaka, K., Yoshida,T., Uryu, T., Yoshida, O., Nakashima, H.,

              Yamamoto, N., Mimura, T. and Kaneko, Y. :

              Synthesis of an inhibitor of human immunodeficiency virus infection.,

              Jpn. J. Cancer Res., 80; 95-98, 1989.

44.                   Nakashima, H., Pauwels, R., Baba, M.,Schols,D., Desmyter, J. and

              De Clercq, E.:

Tetrazolium-based plaque assay for HIV-1 and HIV-2, and its use in the evaluation of antiviral compounds.,

              J. Virol. Methods, 26; 319-330, 1989.　

45.                   Nakashima, H., Okubo, K., Honda, Y., Tamura, T., Matsuda,S. and

              Yamamoto, N.:

Inhibitory effect of glycosides like saponin from soybean on the infectivity of human immunodeficiency virus    in vitro.,

              AIDS, 3; 655-658, 1989.

46.         Tochikura, T. S., Nakashima, H. and Yamamoto, N.:

              Antiviral agents with activity against human retroviruses.,

              J. Acquired Immune Deficiency Syndromes, 2; 441-447, 1989.

47.        Baba, M., Tanaka, H., De Clercq, E., Pauwels, R., Balzarini, J., Schols, D., Nakashima, H., Perno, C. F., Walker, R. T. and Miyasaka, T.:

High specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.,

              Biochem. Biophys. Res. Commun., 165; 1375-1381, 1989.

30.                  Tochikura, T.S., Nakashima, H., Uemura, Y., Goto, T., Suyama, T.,

              Kobayashi, N. and Yamamoto, N.:

Efficacy of an immunoglobulin preparation from HIV caries in preventing HIV replication in vitro.,

              Vox Sang., 54; 138-143, 1988.

31.         Yoshiyama, H., Nakashima, H., Kobayashi, S. and Yamamoto, N.:

Defferential neutralizing capacity to different human immunodeficiency virus (HIV) isolates by rabbit antiseum against LAV: sensitive assays with HTLV-I-positive MT-4 cells.,

              AIDS Res. Human Retroviruses, 4; 91-98, 1988. 

32.         Tochikura, T. S., Nakashima, H., Tanabe, A.and Yamamoto, N.:

 Human immunodeficiency virus (HIV)-induced cell fusion: quantification and its application for the simple and rapide screening of anti-HIV substances in vitro.,

              Virology, 164; 542-546, 1988.

33.         Nakashima,H., Tanabe, A., Tochikura, T. S. and Yamamoto, N.:

Rapid screening methd with a cell multisizer for inhibitors of human immunodeficiency virus-induced cell fusion in vitro.,

              J. Clinic. Microbiol., 26; 1229-1232, 1988.

34.         Tochikura, T. S., Nakashima, H.,Ohashi, Y. and Yamamoto, N.:

Inhibition of replication and cytopathic efect  of human immunodeficiency virus by the extract of culture medium of Lantinus Edodes mycelia in vitro.,

              Med. Microbiol. Immunol., 177; 235-244, 1988.

35.         Yoshida, O., Nakashima, H., Yoshida, T., Kaneko, Y., Yamamoto, I., Matsuzaki, K., Uryu, T. and Yamamoto, N.:

Sulfation of the immunodulating polysaccharide lentinan; a novel strategy for antivirals to human immunodeficiency virus (HIV).,

              Biochem. Phamacol., 37; 2887-2891, 1988.

36.         Matsuda, A., Satoh, M., Nakashima, H., Yamamoto, N. and Ueda, T:

Synthesis and anti-HIV activity of 3'-cyano-2',3'-dideoxythymidine and 3'-cyano-2',3'-didehydro-2',3'-dideoxythymidine.,

              Heterocycles, 27; 2545-2548, 1988.

37.                   Tanabe, A., Nakashima, H., Yoshida, O., Yamamoto, N., Tenmyo, O. and