研修・大学院

2017 Journal Club

Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke

N Engl J Med 2016;374:2313-23.

急性期脳梗塞患者に低用量アルテプラーゼは有効か

Restricting volumes of resuscitation fluid in adults with septic shock after initial management: the CLASSIC randomised, parallel group, multicentre feasibility trial

Intensive Care Med 2016;42:1695–1705.

敗血症性ショックにおける蘇生輸液量制限（CLASSIC study）

Clinical Practice Guidelines for Sustained Neuromuscular Blockade in the Adult Critically Ill Patient

Crit Care Med 2016;44:2079–2103.

重症患者の筋弛緩薬ガイドライン

Hypothermia for Neuroprotection in Convulsive Status Epilepticus

N Engl J Med 2016;375:2457-67.

痙攣重責における低体温療法（HYBERNATUS study）

Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP): Randomized Double-Blind Exploratory Study

Crit Care Med 2016;44:1842-1850.

ストレス潰瘍予防に対するPPIの有効性と有害事象（POP UP study）

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

Crit Care Med. 2017;45:486-552.

Surviving Sepsis Campaign Guideline 2016

Prevention of cardiac surgery‑associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial

Intensive Care Med. 2017 Jan 21. doi: 10.1007/s00134-016-4670-3. [Epub ahead of print]

AKI発症高リスクな心臓外科手術後患者にAKI予防バンドルは有効か（PrevAKI study）

Liberation From Mechanical Ventilation in Critically Ill Adults: An Official American College of Chest Physicians/American Thoracic Society Clinical Practice Guideline

CHEST 2017; 151(1):160-165.

ATS/ACCP人工呼吸器離脱ガイドライン

Association Between Tracheal Intubation During Adult In-Hospital Cardiac Arrest and Survival

JAMA. 2017;317(5):494-506.

成人院内心停止における気管挿管

Video Laryngoscopy vs Direct Laryngoscopy on Successful First-Pass Orotracheal Intubation Among ICU Patients A Randomized Clinical Trial

JAMA. 2017;317(5):483-493.

ICU内での挿管におけるビデオ喉頭鏡（MACMAN trial）

Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department

JAMA. 2017;317(3):301-308.

救急外来患者でqSOFAは院内死亡を予測するか？

Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock after Cardiac Surgery The VANCS Randomized Controlled Trial

Anesthesiology 2017; 126:85-93.

開心術後の血管拡張性ショックに対するバソプレシン

The Effect of Intraaortic Balloon Pumping Under Venoarterial Extracorporeal Membrane Oxygenation on Mortality of Cardiogenic Patients: An Analysis Using a Nationwide Inpatient Database

Crit Care Med 2016; 44:1974–1979.

VA-ECMOとIABP

Effect of Intensive vs Moderate Alveolar Recruitment Strategies Added to Lung-Protective Ventilation on Postoperative Pulmonary Complications A Randomized Clinical Trial

JAMA. 2017;317(14):1422-1432.

リクルートメントマニューバーは術後肺合併症を予防するか

Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis A Randomized Clinical Trial

JAMA. 2017; 317(13):1321-1328.

敗血症に対するデクスメデトミジン（DESIRE trial）

Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis

N Engl J Med. 2017 Mar 21. doi: 10.1056/NEJMoa1701380. [Epub ahead of print]

敗血症性ショックにおけるEGDTの有効性（PRISM）

Ultrasound assessment of volume responsiveness in critically ill surgical patients: Two measurements are better than one

J Trauma Acute Care Surg. 2017;82: 505–511.

輸液反応性の指標としてエコーは有用か？

Prophylactic hydration to protect renal function from intravascular iodinated contrastmaterial in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial

Lancet. 2017 Apr 1;389(10076):1312-1322.

造影剤腎症予防の生理食塩水は有効か？（AMACING study）

Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial

Intensive Care Med. 2017 Apr 18. doi: 10.1007/s00134-017-4786-0. [Epub ahead of print]

壊死性軟部組織感染症に対するIVIG（INSTINCT study）

 

An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome

Am J Respir Crit Care Med. 2017 May 1;195(9):1253-1263.

ATS/ESICM/SCCM：ARDSガイドライン

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial

Lancet 2017; 389: 2105–16

産後出血に対するトラネキサム酸（WOMAN trial）

Intermittent noninvasive ventilation after extubation in patients with chronic respiratory disorders: a multicenter randomized controlled trial (VHYPER)

Intensive Care Med. 2017 Apr 9. doi: 10.1007/s00134-017-4785-1. [Epub ahead of print]

抜管後の間欠的な予防的NIV使用（VHYPER trial）

Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study

Lancet. 2017 May 23. pii: S0140-6736(17)30885-1. doi: 10.1016/S0140-6736(17)30885-1. [Epub ahead of print]

 

肺塞栓症診断におけるYEARSアルゴリズム

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis

N Engl J Med 2017; 376:2235-2244

敗血症性ショックにおける治療開始までの時間と死亡率の関係

Angiotensin II for the Treatment of Vasodilatory Shock

N Engl J Med. 2017 May 21. doi: 10.1056/NEJMoa1704154. [Epub ahead of print]

 アンギオテンシンⅡは血管拡張性ショックに有用か？

Neurological Autoantibody Prevalence in Epilepsy of Unknown Etiology

JAMA Neurol. 2017;74(4):397-402

原因不明のてんかん症例における脳神経に対する自己抗体の陽性頻度

Prevalence and Localization of Pulmonar Embolism in Unexplained Acute Exacerbations of COPD A Systematic Review and Meta-analysis

CHEST 2017; 151(3):544-554

原因不明のCOPD急性増悪における肺塞栓症の有病率

 

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock A Retrospective Before-After Study

CHEST 2017; 151(6):1229-1238

敗血症性ショックに対するビタミンC

Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke

N Engl J Med 2017;376:2437-47.

急性期脳卒中における適切な体位は？（HeadPoST trial）

Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation A Randomized Clinical Trial

JAMA. 2017;317(21):2177-2186.

重症COPDに対する在宅NIV

Recommendations for Methicillin-Resistant Staphylococcus aureus Prevention in Adult ICUs: A Cost-Effectiveness Analysis

Crit Care Med 2017; 45:1304–1310

ICUでのMRSA予防に対する推奨 費用対効果の検討

Multicenter retrospective study of noncompressible torso hemorrhage: Anatomic locations of bleeding and comparison of endovascular versus open approach

J Trauma Acute Care Surg. 2017;83: 11–18.

体幹部の外傷性出血に対する血管内治療と開胸・開腹術の比較

Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest A Randomized Clinical Trial

JAMA. 2017;318(4):341-350.

院外心停止患者に対する体温管理療法の施行時間

Antibiotic Therapy in Comatose Mechanically Ventilated Patients Following Aspiration: Differentiating Pneumonia From Pneumonitis

Crit Care Med 2017; 45:1268–1275

人工呼吸器管理中の誤嚥性肺炎に対する抗菌薬投与

Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With critical Illness A Randomized Clinical Trial

JAMA. 2017;318(8):731-740.

成人重症患者におけるCMV再活性化予防

Prophylactic Corticosteroids for Prevention of Postextubation Stridor and Reintubation in Adults A Systematic Review and Meta-analysis

CHEST 2017; 151(5):1002-1010

抜管後喉頭浮腫に対する予防的ステロイド

Could remifentanil reduce duration of mechanical ventilation in comparison with other opioids for mechanically ventilated patients? A systematic review and metaanalysis

Critical Care (2017) 21:206

レミフェンタニルは人工呼吸器期間を短縮するか

Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs LowPEEP on Mortality in Patients With Acute Respiratory Distress Syndrome A Randomized Clinical Trial

JAMA. doi:10.1001/jama.2017.14171 / Published online September 27, 2017.

ARDSに対する肺リクルートメント

Expert Statements on the Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome

CHEST 2017; 152(2):424-434

Atypical HUSの標準的ケアについてのエキスパート・ステートメント

Outcomes Associated With ResumingWarfarin Treatment After Hemorrhagic Stroke or Traumatic Intracranial Hemorrhage in Patients With Atrial Fibrillation

JAMA Intern Med. 2017;177(4):563-570.

 脳出血を起こした心房細動患者の抗凝固は行うべきか

Guidelines for the diagnosis and management of critical illness‑related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017

Intensive Care Med (2017) 43:1751–1763

重症患者での副腎機能不全ガイドライン2017

Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery A Randomized Clinical Trial

JAMA. 2017;318(14):1346-1357.

術前血圧を参考にした周術期血圧管理は臓器障害を減少させるか？

Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension A Randomized Clinical Trial

JAMA. 2017;318(13):1233-1240.

発展途上国においてSepsisプロトコールは有効か？

Oxygen Therapy in Suspected Acute Myocardial Infarction

N Engl J Med 2017; 377:1240-1249

急性心筋梗塞に対する酸素療法

Effect of Systematic Intensive Care Unit Triage on Long-term Mortality Among Critically Ill Elderly Patients in France A Randomized Clinical Trial

JAMA. 2017;318(15):1450-1459.

高齢者のICU入院は予後を改善させるのか？

Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults

N Engl J Med 2017; 377:1858-1867

赤血球の保存期間は死亡率に影響するのか？

Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial

Crit Care Med 2017; 45:1907–1914

PbtO2+ICPによる重症頭部外傷マネジメントは脳組織低酸素を減少させるか？

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